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As an example, human SET7/9 has recently been reported to methylate Lys189 in the general transcription issue TAF10, resulting in an elevated affinity for RNA polymerase II and transcriptional activation of sure TAF10[-dependent](http://gitea.wholelove.com.tw3000/sheldong177773/8178270/wiki/Thousands-across-the-UK-are-turning-to-private-health-insurance-in-the-current-year%2C-driven-by-NHS-delays.) genes 37 SET7/9 has also been reported to methylate p53, rising the stability of this brief lived tumor-suppressor protein 38 These observations suggest that we should not narrowly define the SET-domain proteins as histone lysine methyltransferases however as an alternative call them protein lysine methyltransferases. + +Cost remains a key concern. + +Some plans require re-underwriting, while others offer fixed-rate contracts. 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